“Rejuvenation with salmon sperm” sounds like clickbait from a tabloid, but behind this provocative phrase actually lies one of the most promising biotechnological ingredients in modern cosmetology. It is used in clinics in South Korea, applied for skin recovery after laser treatments and surgical procedures, and is often described as an alternative to classical biorevitalization. What is really injected under the skin, why does it work, and does “salmon DNA” have a real scientific basis — let’s examine this topic without myths or marketing.

In recent years, in aesthetic medicine and cosmetology, expressions such as “salmon sperm,” “salmon DNA injections,” or “salmon DNA therapy” have been heard more and more often. It sounds provocative, but behind this name there is not an exotic procedure, rather a serious biotechnological field based on the use of purified DNA fragments obtained from the seminal fluid of salmonid fish. These components are widely used both in injectable cosmetology and in cosmetic products, and are considered one of the most promising tools in regenerative medicine.

What Is Actually Used in Cosmetology

These are highly purified biological substances obtained from the seminal fluid of salmonid fish under laboratory conditions. The main active components are:

PDRN (Polydeoxyribonucleotide) — polydeoxyribonucleotides, fragments of DNA.

SDNA (Salmon DNA) — purified salmon DNA.

These molecules undergo a multistage purification process, sterilization, and quality control. The result is a pharmaceutical-grade ingredient that does not contain fish cells, odors, or biological impurities.

Interest in salmon DNA did not originate in cosmetology, but in medicine: PDRN has long been used to accelerate wound healing, treat burns, ulcers, skin injuries, and support tissue recovery after surgical operations. Only later was it observed that these substances possess a pronounced rejuvenating and regenerative effect, which led to their introduction into the aesthetic field.

Why Salmon DNA Specifically

The structure of salmon DNA is biochemically very similar to human DNA. Thanks to this characteristic, it is well recognized by skin cells and can be integrated into regeneration processes. PDRN acts as a source of nucleotides — the “building blocks” necessary for cells to divide and renew.

Its main action is directed toward fibroblasts, the key cells of the dermis responsible for the synthesis of collagen, elastin, and hyaluronic acid. Stimulation of fibroblasts activates skin renewal processes, improving density, elasticity, and the overall appearance of the skin.

In addition, salmon DNA:

• improves microcirculation,
• reduces inflammatory reactions,
• accelerates the recovery of damaged tissues,
• improves cellular metabolism.

Application in Injectable Cosmetology

The most well-known area is injectable procedures, often colloquially called “salmon DNA injections.”

In most cases, they fall under techniques such as:

• biorevitalization,
• mesotherapy,
• regenerative therapy after lasers and peels,
• treatment of post-acne and scar-related changes.

Preparations containing PDRN are injected intradermally or subcutaneously. Unlike classical biorevitalization based solely on hyaluronic acid, the emphasis here is placed not only on hydration, but primarily on deep regeneration.

After a course of treatments, the following are often observed:

• increased skin firmness,
• reduction of fine wrinkles,
• improvement in texture and complexion,
• decreased sensitivity and redness,
• faster recovery after aggressive procedures.

For this reason, such preparations are used not only for rejuvenation, but also as “rehabilitation therapy” after aesthetic device-based treatments.

Use in Cosmetic Products

In addition to injections, salmon DNA extracts are actively incorporated into professional and luxury cosmetics: serums, creams, masks, and ampoules. Concentrations are lower than in medical preparations, but regular use is aimed at maintaining the skin barrier, improving hydration, and slowing aging processes.

In cosmetic products, salmon DNA primarily functions as:

• a regenerating component,
• an anti-inflammatory agent,
• a stimulator of cellular renewal.

This type of cosmetics is especially popular in South Korea and Japan, where biotechnological ingredients traditionally occupy an important place in the beauty industry.

Professional In-Salon Treatments

Salmon DNA is also widely used in professional treatments. It is applied after microneedling with a dermapen, microcurrent therapy, fractional lasers, and chemical peels. At these moments, the skin is particularly receptive to active ingredients, and PDRN helps significantly accelerate healing, reduce the risk of post-procedure complications, and enhance the final result.

Safety and Important Considerations

Despite its unusual origin, preparations based on salmon DNA are considered biocompatible and, when used correctly, demonstrate a high safety profile. However, there are standard contraindications: pregnancy, autoimmune diseases, oncological conditions, active inflammations, and fish allergies.

It is also important to understand that the effect of PDRN is not an immediate “filling” like that of dermal fillers, but a gradual improvement in skin quality through activation of its own natural resources.

Why It Has Become a Trend

The popularity of salmon DNA is explained by a combination of several factors: biomimetic action, proven regenerative properties, versatility of application, and a growing demand for “intelligent” rejuvenation without radical changes in appearance. The beauty industry is increasingly shifting toward restoring and maintaining skin health, and salmon DNA fits perfectly into this concept.

Ultimately, “salmon sperm” is not shocking marketing, but an example of how advances in biotechnology are becoming part of modern aesthetic medicine, offering a more physiological and promising approach to skin care.

The use of salmon DNA in cosmetology is a clear example of how modern biotechnologies are changing the approach to skin care. Today, it is no longer just about masking the signs of aging, but about influencing deep regenerative processes. Preparations based on PDRN and salmon DNA work by stimulating the skin’s own resources, improving its quality, density, and ability to recover. For this reason, they are increasingly used not only in anti-aging programs, but also in regenerative therapies after aggressive procedures.

However, despite the popularity and high biocompatibility of these components, any intervention in the skin — especially injectable ones — remains a medical procedure. There are no universal solutions: what gives an excellent result for one person may prove unsuitable or even risky for another.

Before using preparations based on salmon DNA or undergoing procedures that involve them, it is essential to consult a qualified cosmetic physician. The specialist will assess the condition of the skin, medical history, the presence of possible contraindications, and will define an individualized treatment or care program. A responsible approach to choosing procedures is not a formality, but a key factor in preserving health, beauty, and long-lasting results.